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What is Hodgkin lymphoma?

Hodgkin lymphoma accounts for approximately 10 percent of all lymphomas and approximately 0.6 percent of all cancers diagnosed in the developed world annually. This amounts to approximately 8830 new cases and about 1300 deaths due to HL in the United States annually.
The majority of patients with classical Hodgkin lymphoma present with painless localized enlarged lymph nodes, typically involving the cervical (neck) region.

Hodgkin lymphoma arises from germinal center or post-germinal center B cells in the lymph nodes. Hodgkin lymphoma has a unique cellular composition, containing a minority of neoplastic cells (Reed-Sternberg cells and their variants) in an inflammatory background. It is separated from the other B cell lymphomas based on its unique clinicopathologic features, and can be divided into two major sub-groups, based on the appearance and immunophenotype of the tumor cells.

The diagnosis of Hodgkin lymphoma is made by the evaluation of involved tissue, usually a lymph node biopsy. Excisional biopsies are preferred and large core needle biopsies may be adequate in select cases.

Here, Dr. Tony Talebi discusses the general concepts of Hodgkin lymphoma with Dr. Ann Morhbacher, associate professor of medicine at the University of Southern California and a "top US doctor" as per US world news and world report magazine.   The discussion includes symptoms, diagnosis, staging, genetic implications, secondary cancers, treatment of hodgkin lymphoma,Lymphoma prognosis, what causes lymphoma, signs of lymphoma, lymphoma symptoms, lymphoma, lymphoma stage 4, treatment of lymphoma, lymphoma association, stage four lymphoma, small cell lymphoma, symtoms of lymphoma, causes of lymphoma, lymphoma chemotherapy, what is lymphoma, lymphomas, lymphoma information, lymphoma prevention, stage 4 lymphoma, information about lymphoma, stage iv lymphoma, lymphoma signs, lymphoma symptom, is lymphoma curable, stage 3b lymphoma, lungs cancer symptoms, survival rates for lymphoma, symptoms of lymphoma, lymphoma survivors, lymphoma symptons, lymphoma survival, treatments of lymphoma, symptons of lymphoma, lymphoma statistics, non small cell lymphoma, chemo for lymphoma, lymphoma survival rate, large cell lymphoma, effects of lymphoma, lymphoma screening, lymphoma diagnosis, lymphoma society, lymphoma clinical trials, lymphoma metastasis, survival rate lymphoma, symptom of lymphoma, info on lymphoma, new treatments for lymphoma, how common is lymphoma.


Dr. Ann Morhbacher credentials:


     Associate Professor of Clinical Medicine


     University of Southern California (USC) Norris Comprehensive Cancer Center


      Hematology and Oncology


Dr. Mohrbacher, a graduate of Harvard Medical School, is a devoted educator, researcher and medical practitioner. She has several hematology related research interests and activities, including bone marrow transplantation, and has received thousands of dollars in research grants. She has been published in a number of medical journals and has been invited to lecture on topics including Radioimmunotherapy of non-Hodgkin’s lymphoma and B-cell targeted therapy of rheumatoid arthritis. Dr. Mohrbacher is a member of the Southern California Lymphoma Group and currently belongs to a number of university related committees, such as the Post-Graduate Education Committee and the Clinical Investigations Committee.


  • Harvard and Radcliffe Colleges, Boston, MA, B.A., 1983
  • Doctor of Medicine, Harvard Medical School, Boston, MA, 1987


  • Brigham and Women's Hospital, Boston, MA, 1983 - 1984


  • Brigham and Women's Hospital (Internal Medicine), Boston, MA, 1987 - 1990


  • Clinical Medicine Fellow, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 1990 - 1993
  • Clinical Oncology and Tumor Immunology Fellow, Dana-Farber Cancer Institute, Boston, MA, 1990 - 1993

Board Certification:

  • Medical Oncology
  • Internal Medicine

Professional Society Memberships:

  • Massachusetts Medical Society, 1985
  • American Society of Hematology, 1994
  • Southwest Oncology Group, 1994


  • A.B. Magna Cum Laude, 1983
  • Harvard College Scholarship, 1983
  • ASCO career Development Award, 1995
  • Dr. Mohrbacher was voted a Top Doctor by Pasadena Magazine in 2011.